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Biochemistry

Szerző

Kiadó: W. H. Freeman and Company
Kiadás helye: New York
Kiadás éve:
Kötés típusa: Vászon
Oldalszám: 1.064 oldal
Sorozatcím:
Kötetszám:
Nyelv: Angol  
Méret: 28 cm x 22 cm
ISBN: 0-7167-2009-4
Megjegyzés: 4. kiadás. Színes és fekete-fehér fotókkal, illusztrációkkal.
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Előszó


This is a wonderful time in biochemistry. Recombinant DNA technol-ogy, protein chemistry, and structural biology have come together to reveal the molecular mechanisms of fundamental biological... Tovább

Előszó


This is a wonderful time in biochemistry. Recombinant DNA technol-ogy, protein chemistry, and structural biology have come together to reveal the molecular mechanisms of fundamental biological processes. Many of our dreams of only a few years ago have been fulfilled. One of the fruits of this continuing harvest is a deeper understanding of protein form and function. We now see that proteins are highly sophisticated molecular machines that process energy, matter, and information. Their beautiful molecular ballet is coming into view. Indeed, we can even see the steps taken by a single molecular motor and the flow of ions through a single membrane channel.
These profound advances compel a change in how biochemistry is taught. I have expanded Part II, Proteins: Conformation, Dynamics, and Function, to bring our new understanding of proteins into the core of biochemistry. Membrane channels and pumps, signal transduction cas-cades, antibodies and T-cell receptors, and molecular motors are now presented in Part II rather than in a separate section at the end of the book. The proteins considered in these chapters reveal much about fundamental processes such as free-energy conversion, signal amplification, and molecular recognition. An understanding of proteins as energy-transforming and information-processing devices enriches the study of metabolism. Oxidative phosphorylation and photosynthesis, for example, are more readily understood and appreciated if the proton-pumping mechanism of bacteriorhodopsin is considered first. Likewise, the hor-monal control of metabolism is easier to comprehend if G-protein and tyrosine-kinase cascades are presented first. Another noteworthy change is the new chapter on protein folding and design, an exciting area of inquiry that has broad import.
In 1962, the structures of only two proteins—myoglobin and hemo-globin—were known at atomic resolution. I was fortunate to see them at close rangé while I was a postdoctoral fellow at the Medical Research Council Laboratory of Molecular Biology in Cambridge, England. Max Perutz, John Kendrew, and the young crystallographers in the laboratory instilled in me a deep appreciation of molecular architecture and its im-portance in understanding the molecular basis of life. Now, three decades later, we see the fruition of structural biology. X-ray crystallography, joined by electron crystallography and nuclear magnetic resonance spec-troscopy, have revealed the structures of hundreds of proteins. This wealth of structural information has illuminated and enriched our understanding of how proteins function as enzymes, transporters, motors, signal transducers, and gene regulators. Recurring structural modules have come into view, bringing insight into how proteins evolved. Structural Vissza

Tartalom


Contents
Topics x
Preface to the Fourth Edition xxvii Prefaces to Prior Editions xxx
PARTI Molecular Design of Life 1
1 Prelude 3
2 Protein Structure and Function 17
3 Exploring Proteins 45
4 DNA and RNA: Molecules of Heredity 75
5 Flow of Genetic Information 95
6 Exploring Genes 119
PARTII Proteins: Conformation, Dynamics, and Function 145
7 Portrait of an Allosteric Protein 147
8 Enzymes: Basic Concepts and Kinetics 181
9 Catalytic Strategies 207
10 Regulatory Strategies 237
11 Membrane Structure and Dynamics 263
12 Membrane Channels and Pumps 291
13 Signal Transduction Cascades 325
14 Antibodies and T-Cell Receptors 361
15 Molecular Motors 391
16 Protein Folding and Design 417
RTIII Metaholic Energy: Generation and Storage 441
17 Metabolism: Basic Concepts and Design 443
18 Carbohydrates 463
19 Glycolysis 483
20 Citric Acid Cycle 509
21 Oxidative Phosphorylation 529
22 Pentose Phosphate Pathway and Gluconeogenesis 559
23 Glycogen Metabolism 581
24 Fatty Acid Metabolism 603
25 Aminő Acid Degradation and the Urea Cycle 629
26 Photosynthesis 653
PARTIV Biosynthesis of Building Blocks 683
27 Biosynthesis of Membrane Lipids and Steroids 685
28 Biosynthesis of Aminő Acids and Heme 713
29 Biosynthesis of Nucleotides 739
30 Integration of Metabolism 763
PARTV Genes: Replication and Expression 785
31 DNA Structure, Replication, and Repair 787
32 Gene Rearrangements 819
33 RNA Synthesis and Splicing 841
34 Protein Synthesis 875
35 Protein Targeting 911
36 Control of Gene Expression in Prokai yotes 949
37 Eukaryotic Chromosomes and Gene Expression 975
Appendixes 1012 Answers to Problems 1016 Index 1035-1064

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