Dynamics of proteins and nucleic acids

Fülszöveg

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity.
The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimentál studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function.
The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers)/biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
'McCammon and Harvey's account is easily read and at the same time rewarding to those... Tovább

Fülszöveg

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity.
The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimentál studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function.
The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers)/biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
'McCammon and Harvey's account is easily read and at the same time rewarding to those seeking deeper insight. With its comprehensive and well-balanced list of references, and its review of all the main developments, it will be an inváluable companion to those interested in the dynamics of biological macromolecules.' Nature
This book will undoubtedly serve as a generally good introductory text for expert and non-expert alike.' Times Higher Education Supplement
The cover image shows a model oftransfer RNA usedfor investigating possible large-scale bending motions in that molecule (with thanks to Mike Carson)
Cover design: James Butler Vissza