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Neuropharmacology '85

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Kiadó: Akadémiai Kiadó
Kiadás helye: Budapest
Kiadás éve:
Kötés típusa: Fűzött kemény papírkötés
Oldalszám: 350 oldal
Sorozatcím:
Kötetszám:
Nyelv: Angol  
Méret: 24 cm x 17 cm
ISBN: 963-05-4057-6
Megjegyzés: Fekete-fehér ábrákkal.
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Előszó


PREFACE
This volume is dedicated to Professor Joseph Knoll on the occasion of his 60th birthday.
Dr. Knoll is a graduate of the Budapest University Medicai School (now the Semmelweis University... Tovább

Előszó


PREFACE
This volume is dedicated to Professor Joseph Knoll on the occasion of his 60th birthday.
Dr. Knoll is a graduate of the Budapest University Medicai School (now the Semmelweis University of Medicine) . He has been working in the Department of Pharmacology since finishing his university studies and was appointed professor and department head in 1962.
The broad range of his scientific activity and his originai thinking have made his scientific endeavours extremely fruitful. He is not only outstanding in the area of scientific theories, but he also excels at applying them in practice.
He has devoted himself to extensive research in neuro- and psychopharmacology, a field in which he has developed numerous techniques and new Compounds which won him International fame. He has developed the first selective monoamine oxidase inhibitor, deprenyl (Jumex, Elderpyl) which became a drug used world-wide as the prototype of the selective inhibitors of the B type of MAO and is registered in a number of countries as an adjuvant in the therapy of Parkinson's disease.
He has worked out a new group of non-narcotic analgésies (homopyrimidazols) with special spectrum of activity (one mem-ber of this group, Probon, is a registered drug in Hungary and in many other countries) and a new family of semisynthetic morphine derivatives, (azidomorphines), with remarkably low tolerance and dependence capacities. Using N-substituted noraz-idomorphines as new tools, he succeeded in discriminating Vissza

Fülszöveg


flEUItOPHMIIMCOiOGY 'BS
Editors: K KElEfiiEfl—K (TlfiG VfiR—E. S. VIZI
This volume is dedicateci to Professor J. Knoll on his 60th birthday. It contains the contributioris of distinguished scientists from ali over the world, presenting their recent results in the field of monoamine oxidases and their inhibitors, opioids and opiate receptors, centrai and peripheral neurotransmitter systems, i.e. on scientific topics affected by Professor Knoll's originai ideas. The papers encompass a wide range of research including biochemistry, physiology, pharmacology and clin-ical medicine thus providing a wealth of new information on ali of these aspects.

Tartalom


Preface
MONOAMINE OXIDASES AND THEIR INHIBITORS
Selective irréversible inhibition of monoamine oxidase K.F. TIPTON and Ch.J. FOWLER
Studies on the nature and specific inhibition of monoamine oxidases V.Z. GORKIN
Platelet monoamine oxidase; a marker for central serotonin turnover?
L. ORELAND, Y. ARAI and A. STENSTRÖM
Blood platelets as a model in studies of aminergic reactions
F. MARKWARDT and E. GLUSA
Demise and resurrection of misconceptions about monoamine oxidase Th.P. SINGER
Prevention of tyramine-induced noradrenaline release from rat brain slices by (-)-deprenyl: new insights into the "cheese effect"
M. SANDLER, V. GLOVER and C. PYCOCK
Metabolism of deprenyl in rats
K. MAGYAR and L. TÓTHFALUSI
Recent trends in analysis and préparation of biologically active substances using liquid chromatography H. KALÂSZ
A comparative study of anti-MAO activity of some antidepressants
Â.Vé VALDMAN and E.M. GANKINA
The challenge of Parkinson's disease G. STERN
Treatment of Parkinson's disease
M.D. YAHR 69
Deprenyl in the management of drug induced circannual fluctuations in parkinsonism
W. BIRKMAYER and P. RIEDERER 75
OPIOIDS AND OPIATE RECEPTORS
A genetic approach to opiate mechanisms
A. OLIVERIO and C. CASTELLANO 85
Differentiation between opiate receptors by means of apparent pA2 estimation with CAM, a new type of opiate antagonist
S. FÜRST 93
Opiate and dopamine receptors in the brain of albino Swiss mice: différences between groups differently responding to morphine
J. VETULANI, L. ANTKIEWICZ-MICHALUK and
J. MICHALUK 99
The rôle of hydrophobicity of azidomorphines in the rate of offset of action in guinea-pig ileum
T. FRIEDMANN and K. VALKÖ 105
Pharmacology of D-phenylalanine and other enkephalinase inhibitors
S. EHRENPREIS 111
Comparison of antinociceptive effects of calcitonin and dynorphin intrathecally administered in the rat
S. FERRI, S. CANDELETTI, E. CAVICCHINI, P. ROMUALDI, E. SPERONI and S. SPAMPINATO 119
OTHER CENTRAL NEUROTRANSMITTER SYSTEMS
Psychopharmacological effects of a new dopaminergic agonist, Compound GYKI-32887
J. BORSY 127
The effects of repeated treatment with antidepressant drugs on the action of D-amphetamine and apomorphine in rats
J. MAJ, Z. R0GÓZ, G. SKUZA and H. SOWINSKA I33
H-spiroperidol binding in depression Syndrome
P. RIEDERER, K. JELLINGER and E. GABRIEL
141
Contributions to the influence of dopaminergic mechanisms on body temperature and gas exchange
G. FESZT 149
Brain serotonin and learning. An analysis using para-Br-methyl-amphetamine (pBrMA) as a research tooi
B. KNOLL, J. TIMÁR, S. G Y ARMAT I, Gy. HELD and
G. ZSILLA 157
Effect of para-bromo-methylamphetamine (V-111) on the sexual behavior and reproduction in rats
J. DALLÓ 165
Brain GABA-ergic systém: pharmacological and neuro-chemical ways of régulation
K.S. RAYEVSKY. 171
Participation of GABA-ergic neurotransmission in the régulation of central nervous excitability
V.P. GEORGIEV 177
On the mechanism of action of the nootropic drug meclophenoxate
V. PETKOV 183
Beta adrenergic blocking agents in the treatment of tremors of various origins
T.A. LARSEN, K. BURTON and D.B. CALNE 191
The role of central cholinergic mechanisms in the peripheral adrenergic activation
V.M. VARAGIČ 201
Cholinergic-adrenergic interactions in the genesis of centrogenic cardiac arrhythmias in the rats
B. CUPARENCU, L. SAFTA, V.V. PAPILIAN, V. pANDOR, A. FÁBIAN and J. HORÁK 209
New endogenous food intake inhibitor - satietin. Isolation and properties
J. NAGY 219
Non-conventional communication between neurons
E.S. Vizi 227
Possible function of cysteine sulfinic acid in the central nervous system
H. IWATA 231
Expérimental therapy of seizures induced by endogenous convulsants L-kynurenine and quinolinic acid
I.P. LAPIN 237
Central nervous system and immunoregulation
K. MAŠEK 241
Some drug-induced modifications of stress in calves H. RAŠKOVÁ, Z. URBAN0VÁ, L. ČELEDA, Vü TRCKA, J. ČERNÍ and A. KUBICEK 249
PERIPHERAL NEUROTRANSMITTER SYSTEMS
The cardiovascular effect of GYKI-32 887, a new dopamine agonist
L. TARDOS, L. JASZLITS, J. BERZÉTEY and J. BORSY 257
Effect of cerebral vasodilators on amimal models with impaired cerebral blood flow
L. SZEKERES, K. CSETE and P. ELEK 263
Age-dependent changes in blood supply of the liver and in the hepatic transport in rats
F. VARGA 271
The voltage clamp technique as a tooi in the pharmacology of the heart
K. KELEMEN and R. MARKÓ 277
Effect of biogenic amines, prostaglandins, celluline-A on the calcium-dependent slow depolarization mechanism of the cardiac cell membrane
V. KECSKEMÉTI 283
Purinergic receptors in the adrenergic neurotrans-mission of the heart
J. SZEGI, A.J. SZENTMIKLÓSI and Á. CSEPPENTö 289
Taurine uptake inhibitors are not taurine releasers from platelets
M.K. PAASONEN, E. SOLATUNTURI and M.-L. NIEMINEN 295
The role of histamine in exocrine secretion. Studies in the submandibular gland of the cat
F. ERJAVEC 299
Alpha bungarotoxin inhibits synaptic transmission in the frog sympathetic ganglion
E. MINKER, G. BLAZSÓ and L. GERÖ 307
The response of isolated organs in the different ontogenic periods
S. HUKOVIC and N. MULABEGOVIC 313
Presynaptic activity of dopaminergic agonists on peripheral organs
L. GYÖRGY, M. DÓDA and Zs. ORR 319
Truxillic acids' derivatives D.A. KHARKEVICH
Search for the ideal muscle relaxant F.F. FOLDES
327
333
List of contributors 343
Subject index 347
Megvásárolható példányok
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Neuropharmacology '85 Neuropharmacology '85 Neuropharmacology '85 Neuropharmacology '85 Neuropharmacology '85 Neuropharmacology '85

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