The Biochemical Basis of Neuropharmacology

Szerző

Jack R. Cooper

Floyd E. Bloom

Robert H. Roth

New York

'Jack R. Cooper: The Biochemical Basis of Neuropharmacology ' összes példány

Kiadó:	Oxford University Press
Kiadás helye:	New York
Kiadás éve:	1978
Kötés típusa:	Fűzött keménykötés
Oldalszám:	327 oldal
Sorozatcím:
Kötetszám:
Nyelv:	Angol
Méret:	22 cm x 14 cm
ISBN:	0-19-502346-3
Megjegyzés:	Fekete-fehér fotókkal, ábrákkal.

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Preface to the Third Edition It comes as somewhat of a surprise, albeit a pleasant one, to find ourselves writing a third edition of this book. Frankly, it never occurred to us that its popularity... Tovább

Tartalom

I
Introduction, 3
Cellular Foundations of Neuropharmacology, 9
cytology of the nerve cell
bioelectric properties of the nerve cell
approaches
identification of synaptic transmitters
the steps of synaptic transmission
3 Metabolism in the Central Nervous System, 47
4 | Receptors, 60
definition
assays
identification
kinetics and theories of drug action
5 | Acetylcholine, 73
assay procedures
synthesis
hydrolysis
the genesis of the cholinergic triad in neurons
uptake, storage, and release of ach
actions of ach
the cholinergic receptor
drugs that affect central cholinergic systems
6 | Catecholamines I: General Aspects, 102
methodology
distribution
Contents
LIFE CYCLE OF THE CATECHOLAMINES
AXONAL TRANSPORT
NEUROTRANSMITTER ROLE
PHARMACOLOGY OF CATECHOLAMINE NEURONS
Catecholamines II: CNS Aspects, 161
SYSTEMS OF CATECHOLAMINE PATHWAYS IN THE CNS
CATECHOLAMINE METABOLISM
BIOCHEMICAL ORGANIZATION
PHARMACOLOGY OF CENTRAL CATECHOLAMINE-CONTAINING NEURONS
CATECHOLAMINE THEORY OF AFFECTIVE DISORDER
DOPAMINE HYPOTHESIS OF SCHIZOPHRENIA
Serotonin (5-hydroxytryptamine), 196
BIOSYNTHESIS OF SEROTONIN
PINEAL
CELLULAR EFFECTS OF 5-HT
y-Aminobutyric Acid, Glycine, Glutamic Acid, and
Taurine, 223
GABA
GLYCINE
GLUTAMIC ACID
TAURINE
Neuroactive Peptides, 259
PEPTIDE-SYNTHESIZING ENZYMES AND PEPTIDASES
THYROTROPHIC-RELEASING HORMONE (TRH)
OPIOID PEPTIDES: ENDORPHINS AND ENKEPHALINS
ANGIOTENSIN II
OXYTOCIN AND VASOPRESSIN
LUTEINIZING HORMONE-RELEASING HORMONE (LH-RH)
SUBSTANCE P AND NEUROTENSIN
SOMATOSTATIN (SOMATOTROPIN RELEASE INHIBITING FACTOR [SRIF])
A READER'S GUIDE TO PEPTIDE POACHING
xi
Contents
ii I Cyclic Nucleotides, Prostaglandins, and Histamine, 282
cyclic nucleotides
prostaglandins
histamine
12 Cellular Mechanisms in Memory and Learning, 307
formulating experiments in memory and learning
morphological experiments
cellular models for learning experiments
biochemical experimentation on learning and memory
Index, 323